编辑回信，共与各位前辈讨论

　　编辑回信，共与各位前辈讨论。第一篇sci 终于有回信了，

Reviewer: 1

Comments to the Author（修改后接受）
See attached file.

Reviewer: 2

Comments to the Author
There are several asepcts that need to be improved:

- the title is inadequate: If it is a review of non-surgical therapeutic strategies some alternative treatments are missing: bisphosphonates, iloprost (prostaglandin-analogon (J?ger et al)), hyperbar oxygen treatment, hyperbaric oxygen therapy, non-load weight bearing, Pulsed electromagnetic fields stimulation (Ding et al. ...)
- THus, the result of literature research of these treatments need to be added; or at least some part of them as long as the title will be changed to e.g. pharmaceutical strategies
- THe structure of the manuscript need to be improved: It should be organised in INtroduction, MM, Results, Discussion. After MM there is no further structure by heading.
- The language needs to be improved. There are many very long sentences. In addition spelling should be checked.
- The literature research is incomplete. E.g. Floerkemeier et al. (bone turnover markers failed to predict ....). The literature research needs to be completed.

Detailed:
- after introduction of the abbreviation SONFH it should be used througout the manuscript
- page 1; first paragraph of introduction: “what′s“ is not written english
- please add literature for the statement of the second paragraph of the introduction (multifactorial biomarkers)
- protein-to protein (PPI) – here a word is missing
- page 1: 3rd paragraph of introduction: Various non-surgical (of is too much).
- Check spaces after commata and before brackets.
- Literature should be mentioned at the end of the sentence unless the author′s name is mentioned.

Reviewer: 3

Comments to the Author
1. There are not more outstanding insights of this review than that of related reviews.
2. The title of this review is too big. A profound review for biomarkers related to SONFH pathogenesis and non-surgical therapeutic strategies will be difficult.


结果会怎样？谢谢各位了
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